Eccrine carcinoma does not have a characteristic clinical appreance but does have a hign incidence of metastatic spread. In may arise anywhere in the skin.
The microscopic pattern is that of an adenocarcinoma, which may be confused with metastatic adenocarcinoma. In the classical type the histologic features varies from fairy well-differentiated tubular structures in some areas to anaplastic
carcinoma
in
other areas.
The patient was 51-year-old man who showed a painful, tender, bright red-colored, 4×5cm-sized tumor mass on the right angle of the lower lip for ten years. In the radiological examinations multiple metastatic foci were seen on both lung fields.
Histopathologic findings of the skin and lung biopsy specimens revealed that of the classic type of eccrine carcinoma like the aboce descriptions. Immunocytoclemical atudies showed a positive reactivity to anti-cytokeratin antibody, anti-CEA
antibody,
and anti-S-100 protein on the skin and lung biopsy specimens and no the reactivity to anti-S-100 protein on the lung mass. Electronmicroscopic findings revealed eccrine glandular structrues such as numerous mitochondria and dense core granules in
the
cytoplasm of neoplastic cells.
We report a case of eccrine carcinoma with lung metastases based on the clinical, radiological and histologic findings.(Kor J Dermatol 1995 ; 33(1) : 154~159)
|